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Most Influential in Radiology
Recognizing the movers and shakers in the imaging industry
09.08.08

1. The Alliance for Radiation Safety in Pediatric Imaging
A big message to protect little ones
The Alliance for Radiation Safety in Pediatric Imaging tops this year’s “Most Influential” list because of efforts taken during the past year to protect pediatric patients, while still providing quality imaging studies. The Image Gently™ campaign was launched in January to raise awareness of the opportunities that exist to reduce radiation dose in CT exams performed on children.
There were approximately 4 million pediatric CT scans performed in 2006 – almost triple the number of exams just five years ago. Children are more sensitive to radiation received from imaging scans than adults, and cumulative radiation exposure to their smaller, developing bodies could, over time, have adverse effects.
Founded by the Society for Pediatric Radiology, the American College of Radiology, the American Society of Radiologic Technologists, and the American Association of Physicists in Medicine, the Alliance urges providers who perform pediatric imaging exams to significantly reduce, or “child-size,” the amount of radiation used during a study.
Radiation dose reduction can be accomplished by following a few simple guidelines: eliminating unnecessary scans; scanning only the indicated region; and limiting multiphase exams (pre- and post-contrast, delayed exams), as their diagnostic value often does not outweigh the exposure of higher radiation doses.
Since its inception, the Image Gently campaign has had a significant impact on medical practice, growing exponentially as it attracts national and international attention and participation. The Alliance has expanded to include 26 organizations and has gone global with the addition of the Canadian Association of Radiologists, the Sociedad Latino Americana de Radiología Pediátrica, and the Asian-Oceanic Society for Paediatric Radiology.
In addition to rt image’s top honor this year, the campaign has been honored by a resolution in the U.S. House of Representatives and was nominated for a National Quality Forum award. A recent CT vendor summit was facilitated in Cincinnati, and the campaign received funding to produce a parent information brochure.
Since its launch, more than 1,300 imaging providers representing more than 1,000 facilities have taken the Image Gently pledge to reduce radiation dose used in CT scans on children. The Image Gently Web site (www.imagegently.org) has received nearly 65,000 visits, resulting in more than 6,800 providers downloading the protocols that aid in determining appropriate radiation techniques tailored for pediatric imaging.
“We are so pleased by this enthusiastic response,” says Marilyn Goske, MD, chair of the Alliance for Radiation Safety in Pediatric Imaging. “I have personally heard from radiologic technology students who were inspired to use the Image Gently campaign as their student project – and won first place.”
“Radiology business administrators of large groups have indicated that every member of their 40-person group signed the pledge, and the various Alliance organizations have thrown their support into this campaign. We are honored by their commitment to the goal of the Alliance and the campaign.”
This initiative has fueled RTs, medical physicists, and radiologists to come together to promote radiation protection for children. Image Gently’s success is largely due to the conviction of the diverse organizational representation – proof that those in the field simply want to do what is in the best interests of their youngest patients.
Goske says, “We look forward to having a continued impact on imaging in children through the Alliance and additional work with the vendor community and other initiatives.”
— Deven Kichline

2. U. Joseph Schoepf, MD
King of hearts
U. Joseph Schoepf, MD, is recognized as one of cardiovascular imaging’s most respected leaders, and he’s proud to be considered one of the elite in his field. “Being named among rt image’s ‘Most Influential’ is a tremendous honor and a quite humbling experience,” says Schoepf.
He is the associate professor of radiology and medicine, division of cardiology, director of CT research and co-director of the Center for Advanced Imaging Research at the Medical University of South Carolina in Charleston. His passion lies in cardiothoracic imaging, especially the use of multidetector-row CT for pulmonary embolism and coronary artery disease detection, as well as CT and MRI for ischemic heart disease.
In recent years, Schoepf’s pioneering energies have been largely focused on advancing dual-source CT (DSCT), which uses two parallel tubes and detector configurations to improve temporal resolution and diagnostic quality. “It’s the best temporal resolution that we’ve ever had for structural imaging of the heart with a CT scanner,” says Schoepf.
DSCT also decreases scan times, which reduces radiation exposure to patients, and largely eliminates the need for beta-blockers. Schoepf also sees added benefits from the new technology entering the imaging suite.
“For example, you can determine whether a person has too much iron in the liver. Or, you could edit out calcifications of the vessels, which would allow us to improve our diagnosis,” he says. His groundbreaking work has earned Schoepf a spot on Medical Imaging Magazine’s “Top 10 Cardiovascular Imagers in the Nation” for the second consecutive year.
In addition, Schoepf lends his time to various local, national, and international professional and scientific societies, and serves on numerous board and committee appointments. He is an editorial board member of Radiology, the Journal of Thoracic Imaging and European Radiology, and is a frequent reviewer for countless others. An accomplished author for peer-reviewed journals, Schoepf has also contributed 20 book chapters and has edited two books.
“I am only the frontman of a large group of brilliant, dedicated, and hard-working professionals at the Medical University of South Carolina who work tirelessly to ensure the best possible, most advanced patient care and to further the field of noninvasive cardiovascular imaging,” Schoepf says.
“Together, we will continue our quest to explore new techniques, educate our field in their application, and ensure their appropriate use for the benefit of our patients.”
— D.K.
3. American College of Radiology
Radiology’s enduring voice
For more than 75 years, the American College of Radiology (ACR) has been proud to serve as the “voice of radiology” to elected officials and government agencies. “Through targeted public awareness, educational, clinical research, and advocacy efforts, the ACR is protecting the future of the profession and enhancing the quality of patient care,” says ACR Chair James H. Thrall, MD, FACR.
Congress recently passed the Medicare Improvements for Patients and Providers Act of 2008 (H.R. 6331), which averted a massive overall Medicare physician reimbursement cut. The bill also requires MR, CT, PET, and nuclear medicine exam providers to be accredited by 2012 in order to receive reimbursement.
The ACR worked tirelessly with Congress to provide the information necessary to establish the federal quality standards for imaging included in the legislation. Aside from mammography, there were previously no federally mandated quality standards for medical imaging.
The ACR gained more than $100 million in reimbursement for radiologists nationwide and worked to secure local-level-determined reimbursement for coronary CT angiography. The ACR also spearheaded a 40-percent increase in payments for hospital outpatient interventional procedures, averting a Center for Medicare and Medicaid Services-planned 25-percent payment reduction.
Results of the recent ACR Imaging Network CT Colonography (CTC) Trial helped bring about an American Cancer Society classification of CTC as a recommended screening exam for colorectal cancer. Likewise, initial findings of the Screening Breast Ultrasound for High-Risk Women Trial were widely reported and provide information about the benefits and risks of screening ultrasound as a supplement to mammography.
With more than 100,000 registered Medicare patients to the National Oncologic PET Registry, analysis of the registry data reported that FDG-PET is associated with a 36.5-percent change in the decisions on whether or how to treat a patient’s cancer.
Also in 2008, the College became a founding member of the Alliance for Radiation Safety in Pediatric Imaging, set plans in motion for the “Face of Radiology” branding campaign to educate the public regarding the vital role radiologists play in the healthcare process, and launched the ACR Education Center, which provides comprehensive, interactive radiology education using new educational methods, including simulation.
— D.K.

4. Roland Talanow, MD, PhD
The search stops here
Perhaps the most exciting new development in modernized patient care this year came in the form of Radiology Search, a free search engine designed to streamline and accelerate information inquiries related to radiology-specific and peer-reviewed content.
And no one has been as invested in its growth than the program’s developer, Roland Talanow, MD, PhD, a radiology resident at the Cleveland Clinic. While searching for and finding radiology-related information is seemingly easy with common Internet search engines, such as Google and Yahoo, it can be difficult to find specific pieces of information relative to the query or, the information may be irrelevant.
To ease the burden, Radiology Search begins much like a regular search engine, with the user typing in keywords or phrases. Where the program is different lies in the results it provides: specific results related directly to radiology only, generated through peer-reviewed information.
“I came up with the idea to integrate a search engine, which basically covers everything radiologists may need in their daily work,” says Talanow.
In addition to valid, reliable search results, the site includes an online tutorial that makes finding that information easy, with step-by-step instructions and a list of the system’s features. Through the site, radiologists can also tap into professional societies and skim through a menu of industry journals.
Seminars, continuing medical education workshops, and other accredited activities can be referenced through simple searches, as can radiology cases, teaching files, single radiological images, radiology news, books, vendors, and products.
“All in one view, there will be choices for images, teaching files or publications,” Talanow says. “I also subdivided the searches.”
If the ease and specificity of Radiology Search still isn’t enough, the site can be customized to meet individual user’s needs. With this advanced application, the site can be searched from an outside Web site through a source code, adjusted through the home intranet site.
Talanow says, “You don’t have to open a new window, and you don’t have to go on Radiology Search to conduct the search.” Since its debut at the 2007 Radiological Society of North America’s Scientific Assembly and Annual Meeting, Radiology Search has seen exponential traffic growth as word continues to spread.
Talanow is currently working on several other international projects, which strive in common to promote and to enhance eLearning and to find new concepts of improving medical education. He says, “By bringing together my dedication to advance learning with my computer experience, my ultimate goal is to bring medical education to a new level.”
— D.K.

5. Healthcare Information and Management Systems Society
Advocating the EHR
Founded in 1961, the Healthcare Information and Management Systems Society (HIMSS) remains one of the industry’s flagship organizations, focused on bettering healthcare by means of IT leadership and management systems.
Through advocacy, education, and professional development initiatives, HIMSS unites its more than 20,000 individual international members and more than 350 corporate members to aim for contributions that ensure patients receive top-notch care.
The Society has been a long-standing proponent of refining the electronic health record (EHR) – a longitudinal electronic record of patient health information, such as demographics, medications, past medical history, lab data, and radiology reports, generated by one or more encounters in any care delivery setting.
This enables a complete record to be generated, including evidence-based decision support, quality management, and outcomes reporting – offering physicians more complete information that can aid in faster, more accurate diagnoses and treatments. As part of their efforts in 2008, HIMSS partnered with the Electronic Health Records Vendors Association to elect new executive committee members.
This partnership provides a leadership forum relative to standards development and harmonization, the EHR certification process, healthcare IT interoperability, physician reimbursement solutions, and performance and quality measures.
HIMSS also introduced the Organizational Affiliate Program to help increase knowledge and build consensus among health IT stakeholders. This new program will offer access to educational content, professional development resources, and networking for its members.
H. Stephen Lieber, CAE, HIMSS president and CEO, has lent his endorsement to an amendment to the Protecting Records, Optimizing Treatment and Easing Communication Through Healthcare Technology Act of 2008 (Pro(TECH)T Act, H.R. 6357), proposed by Rep. David Wu, D-Ore. The amendment’s aim is to ensure that future clinicians are prepared for IT practices by training more than 10,000 healthcare technology workers by 2010.
In his letter, Lieber writes, “Your amendment will help to ensure that the next generation of healthcare clinicians is educated and trained in healthcare IT practices and the management of information to improve the delivery and quality of care.”
— D.K.

6. Theresa C. McLoud, MD
Leading the way to progress
As the current president of the Radiological Society of North America (RSNA), the associate radiologist in chief and director of education for the radiology department at Boston-based Massachusetts General Hospital (MGH), and a radiology professor at Harvard Medical School, Theresa C. McLoud, MD, has a vision to improve radiologic education and research.
And, she is set on moving that image forward in the United States and abroad. “RSNA is continually expanding and improving its benefits and educational offerings to the global radiology community,” says McLoud.
“I look forward to the continued collaboration of steadfast volunteers, stellar subspecialty organizations, and dedicated staff to progress even further in our mission to provide the best in education, science, and research.”
With more than 40 years’ experience in the field of radiology, McLoud is leading the way for future generations to follow. A pioneer in thoracic imaging, she has completed extensive research in interstitial lung disease, CT of the thorax, lung cancer imaging, and occupational lung disease.
As a result of these endeavors, she has conducted more than 150 postgraduate courses and has published more than 200 scientific papers, reviews, and book chapters. McLoud has traveled around the world educating professionals to further promote the understanding of thoracic imaging, occupational safety, and global disease.
And, after serving for seven years on the Mine Health Research Advisory Committee of the National Institute for Occupational Safety and Health, McLoud has earned honorary memberships in the Chilean Society of Respiratory Diseases and the Royal Australian and New Zealand College of Radiologists.
One of McLoud’s colleagues, James H. Thrall, MD, FACR, radiologist in chief at MGH, says that McLoud is “a quintessential academic radiologist who is contributing across a diverse set of activities that are crucial to the field of radiology.” She is a “definitive thoracic radiologist,” he says, and “a real ‘go-to’ person for the most challenging and complex cases.”
— Haley Jestice

7. Diane Hirakawa, PhD
Giving veterans a fighting chance
According to a recent study in the American Journal of Psychiatry, veterans are 25 percent to 75 percent more likely than nonveterans to develop some form of lung cancer. Not surprisingly, it is one of the most common diagnoses requiring inpatient care today at Veterans Affairs (VA) hospitals, as they spend more than a half a billion dollars each year on smoking-related disease alone.
However, the five-year survival rate for lung cancer increases to 49 percent from 15 percent when caught early, according to the American Cancer Society. And, only 16 percent of lung cancer cases are detected at this early stage – when it is most treatable.
Chairman and CEO of Miamisburg, Ohio-based Riverain Medical, Diane Hirakawa, PhD, wanted to help bring those numbers down. “The number of veterans diagnosed with lung cancer in this country is alarming,” she says, which is why Hirakawa is campaigning for the early detection of lung cancer this year through CAD technology both in the medical imaging field and on Capitol Hill.
With her recent work with a VA contract for its OnGuard™ Chest X-ray CAD technology, she is paving the way for radiology departments in VA hospitals nationwide. When used in conjunction with the reading of standard digital chest X-rays, OnGuard works to identify solitary pulmonary nodules that may be indicative of early-stage lung cancer.
“The OnGuard system will allow radiologists at VA hospitals across the country to better detect suspicious nodules which may indicate the presence of early-stage lung cancer – thereby increasing survival rates of this deadly disease,” says Hirakawa. She hopes that the contract will help to streamline the process for VA hospitals and other authorized federal agencies to purchase the CAD software.
— H.J.

8. NYU Langone Medical Center
Making strides in Alzheimer’s research
A mind-robbing and debilitating condition, Alzheimer’s disease (AD) is devastating to everyone affected by it. To combat the AD epidemic, New York University (NYU) Langone Medical Center in Manhattan is committed to developing ways to better identify those at high risk.
In July at the Alzheimer’s Association 2008 International Conference in Chicago, NYU Langone presented its findings that brain atrophy and biomarkers could allow for earlier detection of AD.
According to the Medical Center, “By utilizing MRI brain scans and measurements of certain compounds in the cerebrospinal fluid, NYU researchers were able to distinguish individuals who would develop Alzheimer’s disease over a two-year period.” Evaluating data from 23 study participants, the researchers reported groundbreaking results.
In subjects who later developed AD, the researchers discovered significantly higher cerebrospinal fluid levels of phosphorylated tau and other compounds, and atrophy in brain areas linked to learning and memory. At the Alzheimer’s Association Conference, NYU Langone also presented its findings that a maternal history of AD predisposes individuals to the condition.
Utilizing fluorodeoxyglucose PET to image subjects over a two-year period, lead author Lisa Mosconi, PhD, determined that subjects with a maternal history had progressive metabolic reductions in glucose usage – and at a much more rapid rate – in brain areas affected by AD than those with a paternal history or no history.
“Our new study shows that subjects with a mother with Alzheimer’s show similarities with Alzheimer’s patients,” says Mosconi. “They have metabolic reductions in the brain regions that are typically affected by AD, which worsen over time,” she says.
— Keri Forsythe

9. Turi O. Dalaker, MD
Providing insight on Parkinson’s disease
As the lead author of two collaborative studies, Turi O. Dalaker, MD, a doctoral fellow from Norway’s Stavanger University Hospital along with neurology and imaging specialists from Stavanger University Hospital the University of Buffalo in Buffalo, N.Y., and University of Bergen in Norway – is providing new insight on early detection of Parkinson’s disease (PD) using advanced MRI technologies.
Leading the first large-scale analyses of the extent of global, tissue-specific, and regional brain atrophy, and white matter hyperintensities (WMH), Dalaker and researchers discovered brain regions linked to PD based on images showing the status of both white and gray matter,
providing valuable information for medical research.
The results of the research revealed strong implications for measuring the progress of PD and the effects of treatment. One investigation compared brain MRI scans and scores on the Mini-Mental State Examination (MMSE), a standard mental screening test, of 155 patients diagnosed with early-stage PD with those of 101 normal subjects.
WMH are diseased areas of the white matter seen commonly in brain MRI scans in the elderly. “The relationship between higher white matter hyperintensities and lower MMSE scores in PD provide a possible explanation for cognitive impairment in PD,” says Dalaker.
The second study examined whether mild cognitive impairment in early-stage PD is associated with atrophy of a specific brain region. The researchers were also interested in investigating the possible link between mild cognitive impairment in PD and a higher risk of developing dementia.
Both studies were conducted at the University at Buffalo and were presented at this year’s American Academy of Neurology meeting in Chicago. Applying an MRI analytical process called voxel-based morphology, Dalaker and colleagues analyzed high-resolution MRI scans of 43 newly diagnosed PD patients and those of 31 sex-matched normal controls.
They found that the PD patients with mild cognitive impairment showed a trend toward reduced gray matter in the cingulate area, a brain region associated with cognitive performance. “This study shows that cingulate atrophy is associated with early cognitive deficit in PD,” says Dalaker, “and might serve as a possible biomarker for increased risk of developing dementia in PD.”
— H.J.

10. American Association of Physicists in Medicine
Ensuring the health and safety of millions
CT scans have revolutionized medicine – with the many benefits they offer medical imaging professionals, and the millions of patients who undergo them each year. However, this year, a significant amount of discussion concerning radiation dose management has risen in the medical community due to the risks related to CT and its use of X-rays.
The press has also challenged public perceptions of CT scans as it brought this issue to the attention of the patients. Luckily, the American Association of Physicists in Medicine (AAPM) was there to rise to the occasion.
“The medical applications of CT have grown tremendously in the last decade as the technology had become more and more sophisticated,” says Mayo Clinic Medical Physicist Cynthia McCollough, PhD, chair of the AAPM Task Group that authored the report. “In the era of increasingly personalized medicine, the report provides a roadmap for doctors and medical physicists to tailor the CT radiation dosages to individuals.”
As it celebrates its 50th year of advancing the application of physics to the diagnosis and treatment of human disease, the AAPM has provided a great resource to the industry in regard to the standardization of radiation doses.
Aspiring to promote optimal medical imaging practices nationwide, the AAPM helps to ensure the health and safety of the millions of U.S. citizens who undergo CT scans each year. In February, they did just that. The AAPM issued a report recommending standardized ways of reporting radiation doses, educating users on the latest dose-reduction technology.
Targeted at radiologists, medical physicists, and other healthcare professionals, the report outlines the best ways to measure, manage, and prescribe radiation dosages. It also provides an additional overview of ways that doctors can optimize modern CT scanners and reduce the amount of radiation used.
— H.J.

11. Chengbo Wang, PhD
Helping asthma sufferers breathe easier
The medical field now knows more about asthma, thanks to research conducted this year by Chengbo Wang, PhD, assistant professor of radiology at the University of Virginia Health System in Charlottesville. Wang drew national attention with his development of a novel MRI technique that identifies microscopic structural damages deep in the lungs of asthma patients.
Wang says he and his research team used a special type of MRI to detect microstructural changes in the lungs. “We found structural alterations in asthmatics, which were not expected,” he says. “These findings contribute to a new understanding of the pathophysiology of asthma.”
Wang’s study, which was published in the Journal of Magnetic Resonance Imaging, involved 14 healthy volunteers and 14 patients with difficult-to-treat asthma. The research team polarized helium-3 to make it visible for MR imaging. Then, the research subjects inhaled the polarized helium-3 gas, and MR images of the lung were obtained.
These images measured how far the helium atoms could move in the lung. Researchers found that the helium-3 atoms moved a greater distance in the lungs of patients with asthma than in healthy subjects, indicating that there are subtle lung structural differences between asthmatics and healthy volunteers.
For his new work in detecting asthma, Wang received the prestigious W.S. Moore Young Investigator Award for Clinical Science from the International Society for Magnetic Resonance in Medicine (ISMRM).
“The award committee received a record number of applications this year, and Dr. Wang’s work stood out for its innovative approach and excellent presentation,” says Vivian Lee, MD, PhD, president of ISMRM.
— Jane Kollmer

12. National Jewish Medical Center
Furthering a common vision
Desiring a new era in medicine, the National Jewish Medical Center in Denver is looking to hasten the pace of its healthcare community. Armed with a mission to promote a proactive model of personalized healthcare, the facility is putting words into action.
One step is complete: National Jewish has formed an alliance to tackle the task at hand. National Jewish has recently partnered with Malvern, Pa.-based Siemens Medical Solutions USA Inc., with plans to integrate Siemens' imaging technology throughout the institution.
Sharing a common vision and mission to provide personalized care, they hope to improve their diagnoses of respiratory, cardiac, and rheumatologic diseases. Of particular importance will be the Institute for Advanced Biomedical Imaging™, where much of the patient care and collaborative research planned for this alliance will be conducted.
“Together, we will be leaders in bringing forward the concept of advanced diagnostics, which merges imaging and the clinical reference laboratories,” says Michael Salem, MD, president and CEO of National Jewish. He hopes to integrate the facility’s research and clinical efforts at the point of the patient, so that each patient can take advantage of the latest technological innovations.
With its alliance with Siemens, National Jewish’s Institute for Advanced Biomedical Imaging is scheduled to open in 2009 and will house two Siemens CT systems and one PET/CT system, replacing the hospital’s current CT scanner. They will also be integrating a RIS and PACS solution.
Heinrich Kolem, CEO of Siemens Medical, says, “We are excited about our collaboration with National Jewish and look forward to supporting the organization with new clinical pathways and workflows for improved quality and patient care.”
— H.J.

13. Molecular Breast Imaging
Technology Breast cancer’s newest foe
There isn’t a woman in the world who wants to find out that she has breast cancer, especially if it could have been detected. While mammograms work well to detect cancers in most women, those who have dense breasts are not as likely to reap its benefits.
This is because cancer can be easily hidden among dense tissue on a mammogram. However, new technology that is enhancing patient care for women is molecular breast imaging (MBI) technology. Within the last six years, Rochester, Minn.-based Mayo Clinic Rochester researchers have been developing MBI technology in hopes to advance nuclear medicine-based technology.
The technology uses a pair of small gamma cameras specifically designed for imaging the breast to detect functional activity. And, since the technology is not affected by dense breast tissue, radiology professionals are able to image the behavior of the cancer as opposed to the appearance of cancer on a mammogram.
MBI is certainly proving its worth. For instance, at the Department of Defense’s annual Era of Hope breast cancer meeting this year, Mayo Clinic researcher Carrie Beth Hruska, PhD, presented some promising results.
In one of her studies where she and colleagues performed MBI and MRI in 48 women – 42 of whom had suspicious areas on previous examination and six who were at high risk for breast cancer – a total of 54 cancers were diagnosed in 32 patients.
“This was a retrospective look at patients who were not served well by mammography,” Hruska explains. “The sensitivity and specificity of MBI were comparable with MRI,” she says. “As MRI is being used more and more, cost will become a major factor. MBI costs four to six times less than MRI.”
The results of her study showed that MBI not only improved imaging characteristics, but it is also more cost-effective. Although MBI is currently only available at the Mayo Clinic, right now, Hruska believes it will be become more widespread in the near future.
— H.J.

14. Mark Kuo, MD
A master multitasker
Last year, Scottsdale Medical Imaging Ltd. (SMIL) made the rt image’s “Most Notable” list for the company’s continued dedication to research. In addition, SMIL has made large strides with customer service, including creating a facility dedicated to women’s imaging in order to increase comfort and accessibility, as well as utilizing the latest technology.
And, since SMIL has continued to participate in large national studies and has become one of the leading enrollers/participants among educational institutions and hospitals – it’s high time to give credit where credit is due. The man behind much of SMIL’s success is Mark Kuo, MD.
For more than two years, Kuo has mastered the art of multitasking. A leading researcher on the largest national, multicenter trial comparing virtual colonoscopy and conventional colonoscopy, Kuo has been a man with a plan in an effort to promote medical imaging.
Having dedicated a large amount of his time, effort, and expertise into making Scottsdale Medical Imaging the highest enrolling site of the trial, he was simultaneously maintaining his regular practice, as well. Kuo is a refreshing addition to rt image’s “Most Influential” list because of his generous contributions to advance virtual colonoscopy.
— H.J.

15. University of Texas Southwestern Medical Center
Healing hearts in the ‘Heartland’
Located in the heart of Dallas, the University of Texas (UT) Southwestern Medical Center certainly lives up to the city’s motto, “Think Big.” As one out of only three hospitals in North Texas that made U.S. News & World Report’s America’s Best Hospitals 2008 list, UT Southwestern is noted for its numerous subspecialties and medical advancements.
One innovation developed by UT Southwestern this year is a new MRI technique that can detect subtle, yet serious, brain injuries. In situations where the brain abruptly stops moving – for instance, car accidents – the blunt impact can severely injure nerve cells.
Previously, this injury could not be identified via CT, and MRI detection was often inconsistent. However, thanks to the new technique, which utilizes a mathematical analysis called diffusion tensor tractography to identify diffuse axonal injury, car accident victims may have better outcomes.
“This is a new way of measuring a common injury that has been overlooked,” says study author Ramon Diaz-Arrastia, MD, PhD. “No matter how many seatbelts and airbags there are, if you hit a tree at 50 miles an hour, you’re going to have this kind of injury. It may account for up to half of the traumatic brain injuries from car accidents.”
Another recent medical breakthrough by UT Southwestern is that adding CT scanning to current risk-assessment models may determine more patients at high risk for heart disease. Drawing upon data from UT Southwestern’s Dallas Heart Study, researchers discovered that CT effectively detected cardiac calcium deposits and blockages.
“In our sample of participants in the Dallas Heart Study, we found that by applying [Screening for Heart Attack Prevention and Education] recommendations, compared with the current guidelines (NCEP-ATP III), there was a 27-percent relative increase in the proportion of patients who would need liquid-lowering therapy,” concludes senior author James de Lamos, MD.
— K.F.

16. David S. Harrington
Turning around healthcare
With an impressive and extensive background in many arenas of healthcare delivery management, David S. Harrington is a true Renaissance man. This decorated Vietnam veteran has held positions in healthcare that have allowed him to develop a unique and insightful leadership style, leading him to become the “go-to” person for many entities that are seeking to initiate or remediate health service ventures.
As one of the few senior healthcare managers with experience as an executive with health plans, hospitals, and physician-owned enterprises, Harrington has consistently demonstrated his ability to move a company to a higher level of excellence. And, his track record proves it.
In 1997, as CEO of a physician-owned management services organization, he led the sale of the business on behalf of more than 40 owners and 600 MD members. In 1998, he formulated a turnaround plan for a network of 12,000 physicians and 110 hospitals.
Currently the CEO of Dallas-based International Radiology Group, Chicago-based American Imaging Management (AIM), and his own consulting firm, Sussex, Wis.-based DASH Business Group, Harrington continues to be a driving force behind changes in healthcare. From a corporate management perspective, Harrington’s leadership has guided AIM into an unprecedented period of growth.
Between 2001 and 2008, the number of health plan members covered under AIM’s programs increased from 2 million to more than 28 million. During that same period, AIM’s program coverage increased from four states to 33 states. As important, during Harrington’s tenure as CEO, AIM has maintained a 100-percent customer retention rating.
Under his leadership, he has transformed the company and the industry through a commitment to his vision of leveraging technology to improve service, quality, and transparency in diagnostic imaging management. Harrington’s vision has fundamentally restructured the imaging management industry from an inefficient call center-based activity to a high-volume, Web-based service model.
— J.K.

17. Massachusetts Institute of Technology
Finding the source
The Picower Institute for Learning and Memory at Boston-based Massachusetts Institute of Technology (MIT) focuses their diverse array of scientists on a single mission: unraveling the mechanisms that drive the human brain – a pursuit that has contributed to medical imaging’s understanding of diseases of the brain.
Imaging techniques, such as functional MRI (fMRI), have rapidly transformed the field of neuroscience. The scans’ reds, oranges, yellows, and blues represent distinct changes in bloodflow and volume triggered by neural activity. But, until the recent MIT study, no one was sure why this worked.
In the study, MIT researchers have shown, for the first time, that star-shaped brain cells called “astrocytes” are what make noninvasive brain scans possible. The study shows that, contrary to popular belief, astrocytes influence complex neuronal computations, such as the duration and selectivity of brain cell responses to stimuli, yet their chemical signals had rendered them invisible to research methods that monitor electrical activity.
Researchers found that astrocytes receive signals directly from neurons and provide their own neuron-like responses to directly regulate bloodflow – the missing link between neurons and blood vessels, without which fMRI does not work.
“This work shows that astrocytes respond exquisitely to sensory drive, regulate local bloodflow in the cortex, and even influence neuronal responses,” says study co-author Mriganka Sur, PhD, Sherman Fairchild professor of neuroscience, and head of the Department of Brain and Cognitive Sciences at MIT.
“Astrocytes are implicated in many brain disorders and express a very large number of genes that are in the brain. Their role is crucial for understanding brain dysfunction, as well as for developing potential therapeutics.”
— Bob Stott

18. Robert Min, MD, MBA, FSIR, FACPh
Pushing the envelope in interventional radiology
Some people are influential because their passion to improve healthcare courses through their veins. And for some, like Robert Min, MD, MBA, FSIR, FACPh, want to ensure that everyone’s veins are as healthy as possible. In fact, Min has invented many of the techniques that are used in treating venous conditions today.
One such technique is endovenous laser therapy for treating a condition in which the leg’s veins cannot effectively return blood to the heart, called venous insufficiency. The minimally invasive technique Min pioneered 10 years ago is still being used by thousands of physicians around the world to treat a variety of conditions, including varicose veins.
Min also developed transcatheter duplex-guided sclerotherapy, another minimally invasive method of treating venous insufficiency. Venous reflux is one of the country’s most prevalent healthcare conditions, affecting tens of millions of people at a cost of billions of dollars.
Despite causing symptoms including leg pain and medical problems, such as skin ulceration, venous conditions are often poorly understood, misdiagnosed, and improperly treated. Min’s career has focused on increasing awareness of venous conditions, bettering diagnoses, and modernizing and improving therapies.
This year, Min was appointed radiologist in chief at NewYork-Presbyterian Hospital/Weill Cornell Medical Center in New York City and chairman of radiology at Weill Cornell Medical College, where he is also associate professor of radiology and director of Weill Cornell Vascular.
Under Min’s direction, Weill Cornell Vascular has become an internationally recognized center for the management of venous reflux. Min’s other areas of clinical and research interests include noninvasive treatments of tumors. “I am committed to redefining the field of radiology and the role of radiologists,” says Min.
“While new developments in technologies will certainly improve what we are able to do, the single most important factor is providing not only the best, but complete, care for our patients. I believe that being more involved in patient care, beginning with initial evaluation and continuing through follow-up, will lead directly to better outcomes.”
— J.K.

19. J. Martin Pfaff, PhD
Witness to the dawn of PACS
J. Martin Pfaff, PhD, has a history that traces itself to the dawn of the PACS technology era. After completing his undergraduate degree at Stanford and then his doctorate in medical physics at the University of California – Los Angeles, Pfaff found a career in medical imaging that launched him right to the cutting-edge of technology.
As a research scientist at Los Angeles-based Cedars-Sinai Medical Center, Pfaff quickly gained experience in image processing. One of his first achievements included developing early image-processing techniques to determine the morphological characteristics of coronary arteries using early digital subtraction angiography systems.
At that time, the power behind computers was limited to barely more than today’s handheld calculators. Spurred by the images from early MR phase-contrast pulse sequences and the clinical impact of maximum-intensity projection image processing on MR angiography, Pfaff built a PACS, which was called Rational Imaging PACS.
Those initial versions of PACS met resistance from radiologists, who complained about reliability and the slow speed of digital reading. But, radiologists endured in the hopes of reducing film costs, improving service for the referral base, and providing more personalized service.
Eventually, with improvements in computer technology, networks, and software design, PACS evolved into dedicated reading stations, enterprise image distribution, and workflow-enabled systems.
Pfaff himself pioneered many of the capabilities now available across the industry, including anatomic grouping, dynamic cross-referencing, stacked image displays with mouse scroll, user-configurable hanging protocols, paper film, key-image summaries, and anatomic triangulation using a distributed architecture with image manager coordination.
And, as the current president of Bell Canyon, Calif.-based Intuitive Imaging Informatics LLC, Pfaff remains a mover and shaker in the PACS industry.
“It is very gratifying to watch and contribute to the evolution of radiology practice over the years,” says Pfaff. In a business where sites frequently change PACS vendors every three to four years, Pfaff is proud that he has customers that are celebrating their 15th consecutive year with his technology.
— J.K.

20. PET/MRI
The future of fusion
It’s common knowledge that two imaging systems are better than one, but what happens when two of the most advanced systems available are fused into one machine?
Following in the footsteps of other hybrid technologies, such as PET/CT and SPECT/CT, the novelty of a PET/MRI imaging system holds vast potential for stroke patients, allowing doctors to study which brain tissues might be salvageable after a stroke.
Working on two different levels, the fusion of PET and MRI images has granted a more encompassing view of the body’s internal workings. On one level, the PET system tracks the movement of radiotracers through the body, targeted to specific organs, bones or tissues, providing precise pictures of the area of the body and molecular images of the body’s biological functions.
However, since PET does not image soft tissue as well as MRI, or have the same degree of flexibility in providing functional and physiologic information, the subsequent MRI scan effectively fills in the gaps in the anatomic scan.
Problems in composite images arise when researchers attempt to correlate data from PET and MRI, as images obtained on separate systems must be aligned using software that looks for identical landmarks on the two images.
This can be challenging when it comes to organs in the thorax and abdomen, which can easily be displaced or change shape when a patient is moved between scanners. A hybrid PET/MRI scanner would reduce imaging time and potentially increase patient throughput. A combined unit might also avoid errors due to a partial mismatch of images caused by variations in patient position in the separate scanners.
Furthermore, prototype PET/MR systems allow simultaneous measurement of anatomy, functionality, and biochemistry of the body’s tissues and cells, enabling researchers to correlate MR and PET data in a way that was previously impossible.
— B.S.

(Bob Lukin, MD, holding award in middle)
21. Bob Lukin, MD
Neuroradiology’s gold standard
The Olympics may be over, but at least one more American is bringing home the gold. Earlier this year, the American Society of Neuroradiology (ASNR) awarded Robert Lukin, MD, with their Gold Medal, in honor of his extensive contributions to the field of neuroradiology.
The University of Cincinnati (UC) professor of radiology has, first and foremost, placed a high value on improving the education of the next generation of neuroradiologists, having personally participated in the training of more than 300 residents and 60 neuroradiology fellows during his career. Having led the UC radiology department for 15 years as its third radiology chair, Lukin recently stepped down in order to focus on more extensive clinical activities.
As a stalwart trustee on the American Board of Radiology and an active member of 30 years, Lukin has also been integral in developing subspecialty certification for neuroradiology, namely the formation of subspecialty certification exams, which allowed neuroradiologists to be certified and examined within their subspecialty.
Serving as part of the ASNR’s executive committee for more than 14 years, Lukin has been responsible for managing focal issues involving neuroradiology certification. Subspecialty radiology training allows groups to stay in the forefront of other specialties in each selected area, and Lukin has been instrumental in spreading awareness among insurance providers and private-practice groups about the benefit of subspecialty neuroradiology training.
Lukin has continued to encourage radiology practices to promote subspecialty training among their residents who are interviewing for positions in their practices.
— B.S.
22. Ultrasound Technologists
A sound investment
Among the staffing fluctuations seen in every modality, one area in particular that has been making noise in 2008 is the shortage of ultrasound technologists. The U.S. Department of Labor has projected the need for an additional 23,000 ultrasound technologists to enter the field by 2014.
As the aging baby boomer generation continues into its golden years, the demand for imaging procedures is expected to grow to nearly half a billion outpatients and 100 million inpatient scans.
With the nation’s aging population, as well as a looming healthcare staffing crisis, healthcare administrators will soon feel the pressure to improve retention and increase recruitment efforts for ultrasound technologists. There is also an increasing need for hospitals to fill urgent radiology department needs and retain existing providers.
In its 2008 Radiology Compensation Review survey, the Dallas-based healthcare recruiting firm, RadSciences Group, reports that while its healthcare clients found radiography, CT, MRI, and nuclear medicine recruitment easier in 2007 compared to previous years, sonographers were scarce by comparison.
The survey showed a particularly high demand for interventional technologists, as well as vascular and cardiac sonographers. While healthcare facilities may be scouring for available sonographers, according to the survey, they are looking for experience even more.
Many of the responding healthcare facilities reported that they would not consider applicants with less than one to two years of viable, concrete experience. Others responded that they also require applicants to be adept in both general ultrasound and vascular studies, presumably to maximize potential to fill the ultrasound gaps in various areas of the facility.
— B.S.

23. John W. Babich, PhD
A great mind in molecular imaging
Molecular imaging poses many mysteries, and most scientists have only begun to scratch the surface. With many of its capabilities remaining to be discovered and many of its applications yet to be integrated into standardized treatment, molecular imaging has captured the attention of the medical community as the next generation in diagnostic imaging.
Just ask John W. Babich, PhD, who has been an active researcher in the field of molecular imaging and targeted radionuclide therapy for the past 25 years.
Prior to founding Cambridge, Mass.-based Molecular Insight Pharmaceuticals Inc. in 1997, Babich was assistant professor of radiology at Harvard Medical School and a staff radiopharmaceutical chemist at Massachusetts General Hospital in Boston. And, he also held a position as principal scientist and head of the radiopharmaceutical section at the Institute of Cancer Research in England.
The amount of research Babich has conducted over the years has enabled him to be considered one of the foremost leaders in the advancement of molecular imaging. His current research efforts focus on molecular imaging in cardiovascular disease, oncology, and neurology.
His previous research experience includes the detection of breast and colorectal cancer using monoclonal antibodies, pharmacological, and in vivo biological studies of novel, small molecules for targeted therapy of neuroblastoma; the use of peptide-based molecular imaging agents for the detection of infection and cancer; and the use of PET for the study of drug behavior in humans.
On top of research, Babich is also the brains behind many of the products currently used for molecular imaging. He is inventor or co-inventor of seven issued and pending patents licensed to or property of Molecular Insight Pharmaceuticals Inc. He is also co-inventor of a cardiac imaging product currently marketed by Hazelwood, Mo.-based Mallinckrodt-TycoHealthcare Inc., called Ultra-Tag.
Babich also recently served as president of the Society of Nuclear Medicine’s Radiopharmaceutical Science Council. With more than 100 research articles in a variety of peer-reviewed journals, as well as several book chapters and invited reviews, under his belt, Babich is recognized in the community as a fountain of information.
— J.K.

24. Kattesh Katti, MScEd, PhD
Man with a gold thumb
Among accolades in areas of chemistry, physics, and radiochemistry, Kattesh Katti, MScEd, PhD, Margaret Proctor Mulligan professor in medical research at the University of Missouri, has also built a worldwide reputation on the back of his contribution to nanomedicine, namely the development of “bio-friendly” gold nanoparticles.
Katti’s original development of bombesin peptide conjugated gold nanoparticles (BBN-AuNPs) has recently become an even greater step in nanomedicine, since it has been demonstrated that BBN-AuNPs are effective as X-ray contrast enhancers in molecular imaging of prostate and breast tumors through X-ray CT imaging.
This research is expected to contribute toward early diagnosis of gastrin-releasing peptide receptor positive tumors, including prostate, breast, and small cell lung carcinomas. Katti has also played an integral role in bringing about a paradigm shift in the way gold and silver nanoparticles are synthesized for biomedical applications.
His latest discoveries in “green nanotechnology” have provided an open window for the application of biocompatible gold nanoparticles in molecular imaging and therapy. Commonly, nanoparticles have been produced using synthetic chemicals, some of which are known to be toxic to humans, which limits both their safety and their application among the patient population.
Katti’s “environmentally friendly” nanoparticles, composed of goldsalts, soybeans, and water, have garnered attention from experts in a variety of imaging modalities, who see untapped possibilities in this research.
— B.S.

25. Lynn May, MA, CAE
Leaving behind a legacy
When Lynn May, MA, CAE, retires from his 11-year tenure as the CEO of the American Society of Radiologic Technologists (ASRT) in December, he will leave behind a legacy. After all, this is the man who led the ASRT during the height of its growth – from 50,000 to 129,000 members.
Some of May’s key accomplishments include: developing an ASRT government relations program designed to facilitate national and statewide advocacy efforts; establishing the ASRT Education and Research Foundation RT scholarship program; and partnering with the American Registry of Radiologic Technologists and the American College of Radiology to create an advanced practice role for the radiologist assistant.
But May’s biggest contribution to the industry is arguably his campaign for the Consistency, Accuracy, Responsibility and Excellence in Medical Imaging and Radiation Therapy (CARE) bill. After the ASRT House of Delegates voted in 1997 to crusade for federal minimum standards in imaging, May compiled a team of ASRT professionals to represent this cause.
And, each year, ASRT members congregate in Washington, D.C. for the annual “RT in DC” event to lobby for the passage of the CARE bill.
— K.F.





